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We retained the blood

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concentrations of the mother molecule for tertiary amines (imipramine, clomipramine and Amitriptyline ( Elavil

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)). The difference is statistically boots chemist viagra significant (p < 0.001). The subgroup treated with dosages superior to 75 mg/day was more frequently monitored than the subgroup receiving dosages inferior or equal to 75 mg/day, respectively 40/48 (83%), and 8/13 (62%). The aim of our study is to evaluate whether the half doses of tricyclics recommended

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for an elderly person are sufficient in the tracey of an hospitalized patient. 1) The elderly population is on the increase; 2) There is a high prevalence of depression in elderly patients; 3) Depression exposes

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the elderly person to an increased risk of suicide; 4) Depression influences the prognosis of associated organic prescription drugs canada legal some answer to this question, we have

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carried out a retrospective study. We have studied a sample of patients over-65, hospitalized at the Clinique des Maladies Mentales et de l'Encephale, over a period of two years, with a ICD 10 diagnosis of moderate or severe intensity

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major depressive episode,

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and treated effectively with return to the euthymia. It is thus preferable to resort to blood level dosage and to look for a maximum dose tolerance before concluding ineffectuality. Laboratory norms are between 45 and 120 micromol/liter. The population thus selected divided into 4 groups. 13 (21%) received dosages

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inferior ou equal to 75 mg/day and 48 (79%) superior to 75 mg/day. Tricyclic antidepressants

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dosage and depressed elderly inpatients. It is important, for the following reasons, to specify the rules of prescription of tricyclics in elderly patients. The

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percentage observed were compared using the Khi2 test with Yates correction. Is it rightful to prescribe tricyclic antidepressants at half-dose to hospitalized elderly people. A retrospective pharmaco-epidemiologic studyIt is recommended to reduce by one half the dosages of tricyclic antidepressants

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for patients over 65 years of age, in order to avert the occurrence of side-effects. The analysis of dosages used sho that:--among the dosages effected upon

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patients receiving doses inferior or equal to 75 mg/day, 1 (12.5%) exceeded the maximal value of therapeutic range.--Among

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the dosages effected upon patients receiving dosages superior to 75 mg/day, 9 (22%) exceeded the maximal value of the therapeutic range. Mean creatinemia was 83.73 mmol/l

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(SD. This allows one to monitor whether the blood levels obtained are included in the therapeutic range; to avoid toxic doses and to check weak compliance in the elderly patient. Among the 61 patients treated with imipramine, blood level dosage was practised on 48 patients (79%). The routine practice of imipraminic blood dosages allo the comparison of blood levels obtained among patients treated with posologies inferior or equal to 75 mg/day imipraminic, to those treated with more than 75 mg/day imipraminic for a least a week. The maxima of blood levels were respectively. Two subgroup were distinguished. Desipramine 200 ng/ml, clomipramine 258 ng/ml,

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imipramine 163 ng/ml, Amitriptyline ( Elavil ) 129 ng/ml. The mean dosage found in the sub-group of patients treated with dosages superior to 75 mg/day was 140 mg/day (SD.

With the elderly subject, the systematic prescription of half-dose tricyclics runs the risk of infratherapeutic dosage. The test group consisted of 87 individuals. Creatinemia was prescribed systematically to each patient on entry. In our study, patients were hospitalized and so benefited from closer observation than one can expect in outpatients.

61 (70.1%) were given imipraminics, 10 (11.5%) serotonin recapture inhibitors, 11 (12.7%) other antidepressants essentially of mianserine and 5 (5.7%) treatment by######The imipraminics prescribed were desipramine, imipramine, clomipramine and Amitriptyline ( Elavil ). In this particular context, the dosages used are close to those advocated for the general population. Our findings do not oppose the use, for the elderly hospitalized depressive, of doses of imipraminics close to those of a young subject. This difference is statistically nonsignificant (p >

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0.10). Research for evidence in favor of toxicity (fall, delirium, convulsion, reduction of dosage before discharge), was done through revision of patients' clinical files. Only patients with normal renal function were retained.

To confirm these results it would be desirable to amil out o prospective study, including a systematised evaluation of adverse effects and a comparison of clinical effectiveness for parallel groups of elderly patients receiving different doses of imipraminic antidepressants.. The average age was 71.3 years (SD. The samples were taken after at least seven days of treatment at the same dose, and twelve to thirteen hours after the last taking.

On revision of clinical files, no patient presented any element that might lead one to suspect toxicity such as defined in quot;Objectives and Methodsquot;.